承担项目（主持） [1] 国家自然科学基金面上项目，糖类受体靶向性近红外荧光探针的构建及在炎症性肠病成像中的应用研究，2022-2025； [2] 国家自然科学基金面上项目，基于缺氧诱导释放的近红外诊疗探针的构建及其初步生物医学应用研究，2018-2021； [3] 国家自然科学基金青年项目，基于能量转移机理的蛋白激酶比率荧光分子探针的设计合成及生物医学应用，2011-2013； [4] 湖南省自然科学基金项目面上项目，双模态成像探针的构建及在炎症性肠病早期诊断中的应用研究，2021-2023； [5] 湖南省自然科学基金项目青年人才培养基金，定位线粒体的比率型三磷酸腺苷荧光探针的研究，2015-2017； [6] 湖南省自然科学基金项目面上项目，能量转移型蛋白激酶荧光探针的研究，2011-2013； [7] 中国博士后科学基金特别资助项目，定位线粒体的比率型荧光探针的研究，2015-2016； [8] 中国博士后科学基金面上项目，能量转移型荧光探针的研究，2014-2016； [9] 湖南省教育厅重点项目，缺氧诊疗荧光探针的研究，2019-2021； [10] 湖南省教育厅优秀青年项目，用于三磷酸腺苷定位和检测的双功能比率荧光探针的构建及细胞成像研究，2016-2018。 近5年发表论文（通讯作者） [1] Accurate fluorescence diagnosis of cancer based on sequential detection of hydrogen sulfide and pH, Analytical Chemistry, 2021, 93, 11826-11835. (IF: 6.986) [2] Monitoring the fluctuation of hydrogen peroxide in diabetes and its complications with a novel near-infrared fluorescent probe, Analytical Chemistry, 2021, 93, 3301-3307. (IF: 6.986) [3] Construction of NIR and ratiometric fluorescent probe for monitoring carbon monoxide under oxidative stress in zebrafish, Analytical Chemistry, 2021, 93, 2510-2518. (IF: 6.986) [4] NAD(P)H-triggered probe for dual-modal imaging during energy metabolism and novel strategy of enhanced photothermal therapy in tumor, Biomaterials, 2021, 271, 120736. (IF: 12.479) [5] A novel near-infrared theranostic probe for accurate cancer chemotherapy in vivo by a dual activation strategy, Chemical Communications, 2021, 57, 13768-13771. (IF: 6.222) [6] A near-infrared fluorescence probe for accurately diagnosing cancer by sequential detection of cysteine and H+, Chemical Communications, 2021, 57, 4811-4814. (IF: 6.222) [7] Real-time imaging of alkaline phosphatase activity of diabetes in mice via a near-infrared fluorescent probe, Chemical Communications, 2021, 57, 480-483. (IF: 6.222) [8] A novel HPQ-based fluorescent probe for the visualization of carbon monoxide in zebrafish, Sensors and Actuators B: Chemical, 2021, 340, 129920. (IF: 7.460) [9] A near-infrared fluorescent probe with large Stokes shift for imaging Cys in tumor mice, Analytica Chimica Acta, 2021, 1171, 338655. (IF: 6.558) [10] Novel near-infrared fluorescence probe with large Stokes shift for monitoring CCl4-induced toxic hepatitis, Talanta, 2021, 223, 121720. (IF: 6.057) [11] ATP-responsive near-infrared fluorescence MOF nanoprobe for the controlled release of anticancer drug. Microchimica Acta, 2021, 188, 287. (IF: 5.833) [12] The construction of a near-infrared fluorescent probe with dual advantages for imaging carbon monoxide in cells and in vivo. Analyst, 2021, 146, 118-123. (IF: 4.616) [13] Novel strategy for validating the existence and mechanism of the “gut-liver axis” in vivo by a hypoxia-sensitive NIR fluorescent probe, Analytical Chemistry, 2020, 92, 4244-4250. (IF: 6.986) [14] Near-infrared fluorescence MOF nanoprobe for adenosine triphosphate-guided imaging in colitis, ACS Applied Materials & Interfaces, 2020, 12, 47840-47847. (IF: 9.229) [15] Near-infrared fluorescence probe with a large stokes shift for visualizing hydrogen peroxide in ulcerative colitis mice, Sensors and Actuators B: Chemical, 2020, 320, 128296. (IF: 7.460) [16] A novel hepatocyte-targeting ratiometric fluorescent probe for imaging hydrogen peroxide in zebrafish, Sensors and Actuators B: Chemical, 2020, 313, 128054. (IF: 7.460) [17] A near-infrared fluorescence probe with a large Stokes shift for detecting carbon monoxide in living cells and mice, Dyes and Pigments, 2020, 180, 108517. (IF: 4.889) [18] A facile pH near-infrared fluorescence probe for the diagnosis of cancer in vivo, Dyes and Pigments, 2020, 179, 108402. (IF: 4.889) [19] In-situ imaging of azoreductase activity in the acute and chronic ulcerative colitis mice by a near-infrared fluorescent probe. Analytical Chemistry, 2019, 91, 10901-10907. (IF: 6.986) [20] Fluorescence-guided cancer diagnosis and surgery by a zero cross-talk ratiometric near-infrared γ-glutamyltranspeptidase fluorescent probe. Analytical Chemistry, 2019, 91, 1056-1063. (IF: 6.986) [21] A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation. Chemical Communications, 2019, 55, 14307-14310. (IF: 6.222) [22] A rhodamine-deoxylactam based fluorescent probe for fast and selective detection of nitric oxide in living cells. Talanta, 2019, 197, 436-443. (IF: 6.057) [23] A ratiometric fluorescent probe for the detection of peroxynitrite with simple synthesis and large emission shift and its application in cells image. Dyes and Pigments, 2019, 161, 288-295. (IF: 4.889) [24] A dual-response fluorescent probe for the detection of viscosity and H2S and its application in studying their cross-talk influence in mitochondria. Analytical Chemistry, 2018, 90, 9418-9425. (IF: 6.986) [25] A ratiometric fluorescence probe for peroxynitrite prepared by denovo synthesis and its application in assessing mitochondrial oxidative stress status in cells and in vivo. Chemical Communications, 2018, 54, 11590-11593. (IF: 6.222) [26] Efficient two-photon fluorescent probe for imaging of nitric oxide during endoplasmic reticulum stress. ACS Sensors, 2018, 3, 2311-2319. (IF: 7.711) [27] Detecting and imaging of γ-glutamytranspeptidase activity in serum, live cells and pathological tissues with a high signal stability probe by releasing a precipitating fluorochrome. ACS Sensors, 2018, 3, 1354-1361. (IF: 7.711) [28] Two-photon fluorescence probe for precisely detecting endogenous H2S in lysosome by employing a dual lock system. Sensors and Actuators B: Chemical, 2018, 260, 264-273. (IF: 7.460) [29] An infinite coordination polymer nanoparticles-based near-infrared fluorescent probe with high photostability for endogenous alkalinephosphatase in vivo. Sensors and Actuators B: Chemical, 2018, 255, 3355-3363. (IF: 7.460) [30] Mitochondria-targeted near-infrared fluorescent probe for the detection of carbon monoxide in vivo. Talanta, 2018, 188, 691-700. (IF: 6.057) [31] A facile and sensitive near-infrared fluorescence probe for the detection of endogenous alkaline phosphatase activity in vivo. Analytical Chemistry, 2017, 89, 6854-6860. (IF: 6.986) [32] Real-time monitoring ATP in mitochondrion of living cells: a specific fluorescent probe for ATP by dual recognition sites. Analytical Chemistry, 2017, 89, 1749-1756. (IF: 6.986) [33] A rhodamine-based fluorescent probe with high water solubility and its application in the detection of glutathione with unique specificity. Sensors and Actuators B: Chemical, 2017, 240, 1165-1173. (IF: 7.460) [34] A near-infrared fluorescent probe based on BODIPY derivative with high quantum yield for selective detection of exogenous and endogenous cysteine in biological samples. Analytica Chimica Acta, 2017, 994, 73-81. (IF: 6.558) [35] Borondipyrrolemethene-based fluorescent probe for distinguishing cysteine from biological thiols and its application in cell image. Dyes and Pigments, 2017, 139, 381-387. (IF: 4.889) [36] A near-infrared chemosensor for determination of trivalent aluminum ions in living cells and tissues. Dyes and Pigments, 2017, 136, 817-824. (IF: 4.889) [37] A borondipyrrolemethene-based turn-on fluorescent probe for silver ion with high sensitivity and selectivity and its application in water samples and living cells. Tetrahedron Letters, 2017, 58, 3536-3540. (IF: 2.415) 授权专利 [1] 基于脱氧罗丹明的一氧化氮荧光探针的制备和应用，专利号ZL201811120191.X [2] 一种过氧亚硝基比率型荧光探针的制备和应用，专利号ZL201910474219.8 [3] 基于脱氧罗丹明的一氧化氮荧光探针的制备和应用，专利号ZL201811120191.X [4] 基于半花菁染料的过氧化亚硝基荧光探针的制备和应用，专利号ZL201810233068.2 [5] 一种近红外碱性磷酸酶荧光探针的制备方法和应用，专利号ZL201611230342.8 [6] 一种近红外GSH荧光探针的制备方法和应用，专利号ZL201610321434.0 [7] 基于罗丹明的GSH水溶性荧光探针的制备方法和应用，专利号ZL201610821181.3 [8] 一种基于氟硼吡咯的Cys荧光探针的制备方法和应用，专利号ZL201610902695.1 [9] 一种定位线粒体的ATP荧光探针的制备及应用，专利号ZL201610929418.X [10] 基于罗丹明水溶性汞离子荧光探针的制备方法和应用，专利号ZL201610250556.5 [11] 一种基于芘的铜离子比率型荧光探针及其制备方法和应用，专利号ZL201410846656.5 [12] 一种铬离子比率型荧光探针及其制备方法和应用，专利号ZL201310322506.X 公司产品 [1] 在读：江文丽（博士，董事长奖特等奖），王文新（博士），王之卿（博士），侯美家，闫灵，廖沁婷，付贵勤，顾青松，陈骏涛，钞静静，李婷，陈思思，张会，胡玲，秦崇康 [2] 已毕业：刘娟，夏雨桑，佘遵攀，陈茜茜，赵仪婷，田杨（董事长奖，湖南省优秀硕士学位论文），张烁，周东叶，欧阳娟（国家奖学金，董事长奖特等奖，湖南省优秀硕士学位论文），李宋娇（国家奖学金），谢俊英（国家奖学金，董事长奖），谭凯月，付雅俊，吴银双（国家奖学金），李丹，李芝，唐佳良（国家奖学金），卢曦，邹春香（国家奖学金），孔雪飞（董事长奖），周雨（董事长奖），徐芬（董事长奖） |